Improving the stability of peptidic radiotracers by the introduction of artificial scaffolds: which structure element is most useful?


Bacher L, Fischer G, Litau S, Schirrmacher R, Wängler B, Baller M, Wängler C. J Labelled Comp Radiopharm. 2015 Aug;58(10):395-402. doi: 10.1002/jlcr.3315. Epub 2015 Jul 27.  Peptidic radiotracers are highly potent substances for the specific in vivo imaging of various biological targets with Single Photon Emission Computed Tomography and Positron Emission Tomography. However, some radiolabeled

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Next Step toward Optimization of GRP Receptor Avidities: Determination of the Minimal Distance between BBN(7-14) Units in Peptide Homodimers.


Fischer G, Lindner S, Litau S, Schirrmacher R, Wängler B, Wängler C. Bioconjug Chem. 2015 Aug 19;26(8):1479-83. doi: 10.1021/acs.bioconjchem.5b00362. Epub 2015 Jul 24.  As the gastrin releasing peptide receptor (GRPR) is overexpressed on several tumor types, it represents a promising target for the specific in vivo imaging of these tumors using positron emission tomography (PET).

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Accuracy of percutaneous soft-tissue interventions using a multi-axis, C-arm CT system and 3D laser guidance


Kostrzewa M, Rathmann N, Kara K, Schoenberg SO, Diehl SJ. Eur J Radiol. 2015 Jun 30. pii: S0720-048X(15)30036-X. doi: 10.1016/j.ejrad.2015.06.028. [Epub ahead of print] INTRODUCTION:Purpose of this phantom study was to compare the accuracy of needle placement using a multi-axis, C-arm-based, flat-panel, cone-beam computed tomography system (CBCT guidance) with that under multi-detector computed tomography guidance

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In Vivo Evaluation of 18F-SiFAlin–Modified TATE: A Potential Challenge for 68Ga-DOTATATE, the Clinical Gold Standard for Somatostatin Receptor Imaging with PET


Niedermoser S, Chin J, Wängler C, Kostikov A, Bernard-Gauthier V, Vogler N, Soucy JP, McEwan AJ, Schirrmacher R, and Wängler B J Nucl Med. 2015 Jul;56(7):1100-5. doi: 10.2967/jnumed.114.149583. Epub 2015 May 14. Radiolabeled peptides for tumor imaging with PET that can be produced with kits are currently in the spotlight of radiopharmacy and nuclear medicine.

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From molecular imaging markers to personalized image-guided therapy.


Schönberg SO, Wängler B. Z Med Phys. 2013 Feb;23(1):1-2. doi: 10.1016/j.zemedi.2012.12.004. Epub 2013 Jan 18. PMID: 23333669 [PubMed – indexed for MEDLINE]

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