Publikationen


Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment

29.04.2024

Haag F, Hertel A, Tharmaseelan H, Kuru M, Haselmann V, Brochhausen C, Schönberg SO, Froelich MF. Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment. Rofo. 2024 Mar;196(3):262-272. English. doi: 10.1055/a-2175-4622. Epub 2023 Nov 9. Erratum in: Rofo. 2023 Dec 28;: PMID: 37944935. Abstract With personalized tumor therapy, understanding and addressing the heterogeneity of malignant

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Feasibility of undersampled spiral trajectories in MREPT for fast conductivity imaging

11.04.2024

Özdemir S, Ilicak E, Zapp J, Schad LR, Zöllner FG. Feasibility of undersampled spiral trajectories in MREPT for fast conductivity imaging. Magn Reson Med, 2024, 91 (4), pp.1567-1575 PMID: 38044757DOI: 10.1002/mrm.29952 Abstract Purpose: To investigate spiral-based imaging including trajectories with undersampling as a fast and robust alternative for phase-based magnetic resonance electrical properties tomography (MREPT)

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Development of Novel Hydraulic 3D Printed Actuator Using Electrorheological Fluid for Robotic Endoscopy

23.03.2024

Sadi, F.; Holthausen, J.; Stallkamp, J.; Siegfarth, M. Development of Novel Hydraulic 3D Printed Actuator Using Electrorheological Fluid for Robotic Endoscopy. Actuators 2024, 13, 119. https://doi.org/10.3390/act13040119 Abstract Endoscopy has made a significant and noteworthy contribution to the field of medical science and technology. Nevertheless, its potential remains constrained due to the limited availability of rigid

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pyM2aia: Python interface for mass spectrometry imaging with focus on deep learning

05.03.2024

Cordes, J., Enzlein, T., Hopf, C., & Wolf, I. (2024). pyM2aia: Python interface for mass spectrometry imaging with focus on deep learning. Bioinformatics, 40(3), btae133. https://doi.org/10.1093/bioinformatics/btae133 Abstract Summary Python is the most commonly used language for deep learning (DL). Existing Python packages for mass spectrometry imaging (MSI) data are not optimized for DL tasks. We, therefore, introduce

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Silicon–Fluoride Acceptors (SiFA) for 18F-Radiolabeling: From Bench to Bedside

14.02.2024

Gower-Fry L, Wängler C, Bartenstein P, Beyer L, Lindner S, Jurkschat K, Wängler B, Bailey JJ, Schirrmacher R. (2024) Silicon-FluorideAcceptors (SiFA) for 18F-Radiolabeling: From Bench to Bedside. Methods Mol Biol., 2729, 29-43. https://doi.org/10.1007/978-1-0716-3499-8_3 Abstract Fluorine-18 (18F) is undoubtedly one of the most frequently applied radionuclides for the development of new radiotracers for positron emission tomography

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Computed tomography imaging phenotypes of hepatoblastoma identified from radiomics signatures are associated with the efficacy of neoadjuvant chemotherapy

30.01.2024

Chen Y, Froelich MF, Tharmaseelan H, Jiang H, Wang Y, Li H, Tao M, Gao Y, Wang J, Liu J, Schoenberg SO, Feng S, Weis M. Computed tomography imaging phenotypes of hepatoblastoma identified from radiomics signatures are associated with the efficacy of neoadjuvant chemotherapy. Pediatr Radiol. 2024;54(1):58-67. (0) PMID: 37982901 PMCID: PMC10776468 DOI: 10.1007/s00247-023-05793-5 Abstract

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Photon-counting computed tomography – clinical application in oncological, cardiovascular, and pediatric radiology

11.01.2024

Hagen F, Soschynski M, Weis M, Hagar MT, Krumm P, Ayx I, Taron J, Krauss T, Hein M, Ruile P, von Zur Muehlen C, Schlett CL, Neubauer J, Tsiflikas I, Russe MF, Arnold P, Faby S, Froelich MF, Weiß J, Stein T, Overhoff D, Bongers M, Nikolaou K, Schönberg SO, Bamberg F, Horger M. Photon-counting

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Radiosynthesis of stable 198Au-nanoparticles by neutron activation of αvβ3-specific AuNPs for therapy of tumor angiogenesis

30.11.2023

Davarci G, Wängler C, Eberhardt K, Geppert C, Schirrmacher R, Freudenberg R, Pretze M, Wängler B (2023) Radiosynthesis of stable 198Au-nanoparticles by neutron activation of αvβ3-specific AuNPs for therapy of tumor angiogenesis. Pharmaceuticals, 16(12), 1670. DOI: 10.3390/ph16121670. Abstract This paper reports on the development of stable tumor-specific gold nanoparticles (AuNPs) activated by neutron irradiation as

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CycloSiFA: The Next Generation of Silicon-Based Fluoride Acceptors for Positron Emission Tomography (PET)

18.10.2023

Mawick M, Jaworski C, Bittermann J, Iovkova L, Pu Y, Wängler C, Wängler B, Jurkschat K, Krause N, Schirrmacher R (2023) CycloSiFA: The Next Generation of Silicon-Based Fluoride Acceptors for Positron Emission Tomography (PET). Angewandte Chemie International Edition, 62(50), e202309002. DOI: 10.1002/anie.202309002. Graphical Abstract Cyclic azasilole derivatives undergo ring-opening with 18F– anions under mild conditions

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Good practices for the automated production of 18F-SiFA radiopharmaceuticals

11.10.2023

Blok S, Wängler C, Bartenstein P, Schirrmacher R, Lindner S (2023) Good practices for the automated production of 18F-SiFA radiopharmaceuticals. EJNMMI Radiopharmacy and Chemistry, 8(1), 25. DOI: 10.1186/s41181-023-00215-1. Abstract Background The positron emitting isotope fluorine-18 (18F) possesses almost ideal physicochemical properties for the development of radiotracers for diagnostic molecular imaging employing positron emission tomography (PET).

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