In vitro skin three-dimensional models and their applications


Julia Klicks, Elena von Molitor, Torsten Ertongur-Fauth, Rüdiger Rudolf, Mathias Hafner

Journal of Cellular Biotechnology, vol. 3, no. 1, pp. 21-39, 2017

DOI: 10.3233/JCB-179004

Abstract. Skin fulfils a plethora of eminent physiological functions ranging from physical barrier over immunity shield to
the interface mediating social interaction. Prone to several acquired and inherited diseases, skin is therefore a major target
of pharmaceutical and cosmetic research. The lack of similarity between human and animal skin and rising ethical concerns
in the use of animal models have driven the search for novel realistic three-dimensional skin models. This review provides a
survey of contemporary skin models and compares them in terms of applicability, reliability, cost and complexity.

Keywords: Skin, phenotypic screening, 3D models, pharmaceutical research