Kunte SC, Unterrainer LM, Kunz WG, Winkelmann M, Lindner S, Jurkschat K, Wängler C, Wängler B, Schirrmacher R, Bartenstein P, Belka C, Schichor C, Albert NL, Unterrrainer M (2024) Lenticulostriatal ischemia shows relevant SSTR-expression on PET/CT imaging using the novel SSTR-targeting peptide [18F]SiTATE. Clinical Nuclear Medicine, 49(12), e689–e690.
DOI:: 10.1097/RLU.0000000000005482
A 64-year-old woman with meningioma presented with left-sided lenticulostriatal ischemia following craniotomy and debulking of a sphenoid wing meningioma. For subsequent radiotherapy planning, an SSTR-targeted PET/CT using the novel ligand 18 F-SiTATE was performed 2.5 months thereafter. The meningioma remnants showed transosseous, intrasellar, and perivascular extension around the internal carotid artery with strong SSTR expression. Moreover, there was focal 18 F-SiTATE uptake in the left caudate and corresponding contrast enhancement due to postischemic blood-brain barrier disruption and reactive SSTR expression. Therefore, increased cortical or subcortical SSTR PET signal may be related to ischemic changes even in the subacute stage after initial stroke.
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