{"id":3388,"date":"2022-12-19T12:16:58","date_gmt":"2022-12-19T11:16:58","guid":{"rendered":"http:\/\/www.m2olie.de\/publications\/dynamic-contrast-enhanced-mr-imaging-evaluation-of-perfusional-changes-and-ablation-zone-size-after-combination-embolization-and-ablation-therapy\/"},"modified":"2023-01-04T12:17:42","modified_gmt":"2023-01-04T11:17:42","slug":"dynamic-contrast-enhanced-mr-imaging-evaluation-of-perfusional-changes-and-ablation-zone-size-after-combination-embolization-and-ablation-therapy","status":"publish","type":"publications","link":"https:\/\/www.m2olie.de\/en\/publications\/dynamic-contrast-enhanced-mr-imaging-evaluation-of-perfusional-changes-and-ablation-zone-size-after-combination-embolization-and-ablation-therapy\/","title":{"rendered":"Dynamic Contrast-Enhanced MR Imaging Evaluation of Perfusional Changes and Ablation Zone Size after Combination Embolization and Ablation Therapy"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Jason Chiang, MD, PhD, Hiro Sparks, MD, Johann S. Rink, MD, M. Franca Meloni, MD, Frank Hao, MD, Kyung H. Sung, PhD, and Edward W. Lee, MD, PhD<\/h4>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"publication-title\">Journal of Vascular and Interventional Radiology<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1016\/j.jvir.2022.10.041\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.jvir.2022.10.041<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Available online 8 November 2022<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Received 4 June 2022, Revised 29 September 2022, Accepted 28 October 2022, Available online 8 November 2022.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sectitle0015\">Purpose<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The objectives of this study were to assess the utility of dynamic contrast-enhanced magnetic resonance (MR) imaging in quantifying parenchymal perfusional changes after embolization and to characterize the association between pharmacokinetic (PK) parameters and final microwave ablation volume.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sectitle0020\">Materials and Methods<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">PK parameters from dynamic contrast-enhanced MR imaging were used to quantify perfusional changes in the liver after transarterial embolization of the right or left lobe in a swine liver model (n&nbsp;= 5). Each animal subject subsequently underwent microwave ablation (60 W for 5 minutes) of the embolized and nonembolized liver lobes. Changes in PK parameters from dynamic contrast-enhanced MR imaging were correlated with their respective final microwave ablation volumes in each liver lobe.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sectitle0025\">Results<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Microwave ablation volumes of embolized liver lobes were significantly larger than those of nonembolized liver lobes (28.0 mL \u00b1 6.2 vs 15.1 mL \u00b1 5.2, <em>P<\/em> &lt; .001). PK perfusion parameters were significantly lower in embolized liver lobes than in nonembolized liver lobes (<em>K<\/em><sup>trans<\/sup>&nbsp;= 0.69 min<sup>\u22121<\/sup> \u00b1 0.15 vs 1.52 min<sup>\u22121<\/sup> \u00b1 0.37, <em>P<\/em> &lt; .001; <em>k<\/em><sub>ep<\/sub>&nbsp;= 0.69 min<sup>\u22121<\/sup> \u00b1 0.19 vs 1.54 min<sup>\u22121<\/sup> \u00b1 0.42, <em>P<\/em> &lt; .001). There was a moderate but significant correlation between normalized <em>k<\/em><sub>ep<\/sub> and ablation volume, with each unit increase in normalized <em>k<\/em><sub>ep<\/sub> corresponding to a 9.8-mL decrease in ablation volume (<em>P<\/em>&nbsp;= .035).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"sectitle0030\">Conclusions<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">PK-derived parameters from dynamic contrast-enhanced MR imaging can be used to quantify perfusional changes after transarterial embolization and are directly inversely correlated with final ablation volume.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[],"class_list":["post-3388","publications","type-publications","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications\/3388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications"}],"about":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/types\/publications"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/comments?post=3388"}],"version-history":[{"count":1,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications\/3388\/revisions"}],"predecessor-version":[{"id":3389,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications\/3388\/revisions\/3389"}],"wp:attachment":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/media?parent=3388"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/categories?post=3388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}