{"id":10229,"date":"2026-03-15T20:53:48","date_gmt":"2026-03-15T19:53:48","guid":{"rendered":"https:\/\/www.m2olie.de\/?post_type=publications&#038;p=10229"},"modified":"2026-06-28T20:53:56","modified_gmt":"2026-06-28T18:53:56","slug":"head-to-head-comparison-of-18fsitate-versus-18fdopa-pet-in-patients-with-neuroendocrine-tumors","status":"publish","type":"publications","link":"https:\/\/www.m2olie.de\/en\/publications\/head-to-head-comparison-of-18fsitate-versus-18fdopa-pet-in-patients-with-neuroendocrine-tumors\/","title":{"rendered":"Head to head comparison of [18F]SiTATE versus [18F]DOPA-PET in patients with neuroendocrine tumors"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Roll W,Hadjitheodorou P, Alevroudis E, Kyrou K, Adamou G, Fesas A, W\u00e4ngler B, W\u00e4ngler C, Schirrmacher R, Pourkhessalian MR, Kalogirou C, Tsechelidis I, Vrachimis A (2026) Head to head comparison of [<sup>18<\/sup>F]SiTATE versus [<sup>18<\/sup>F]DOPA-PET in patients with neuroendocrine tumors. <em>European Journal of Nuclear Medicine and Molecular Imaging, 53(3)<\/em>, 1803\u20131810.<br><strong>DOI<\/strong>:\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00259-025-07572-w\" target=\"_blank\" rel=\"noreferrer noopener\">10.1007\/s00259-025-07572-w<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Background:&nbsp;<\/strong>In neuroendocrine tumors molecular imaging methods play a key role, either targeting the somatostatin receptor or catecholamine pathways. [<sup>18<\/sup>F]SiTATE is a somatostatin receptor-targeting peptide that uses silicon fluoride acceptor (SiFA) radiochemistry, overcoming disadvantages of Gallium-68 labelled DOTA compounds. Here we present the first prospective data of [<sup>18<\/sup>F]SiTATE compared to [<sup>18<\/sup>F]DOPA-PET in NET patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Methods:&nbsp;<\/strong>38 patients with suspected neuroendocrine tumors were prospectively included. All patients underwent both [<sup>18<\/sup>F]DOPA-PET and [<sup>18<\/sup>F]SiTATE-PET. The diagnostic performances were compared on a per-patient and per-lesion basis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Results:&nbsp;<\/strong>22 of 38 patients did not show [<sup>18<\/sup>F]DOPA- or [<sup>18<\/sup>F]SiTATE-PET positive disease. [<sup>18<\/sup>F]DOPA-PET was rated as the more accurate imaging modality in three cases and [<sup>18<\/sup>F]SiTATE-PET in four cases. [<sup>18<\/sup>F]SiTATE-PET showed a significantly higher sensitivity on a per lesion basis compared to [<sup>18<\/sup>F]DOPA-PET (<em>n<\/em>\u2009=\u2009143; sensitivity [<sup>18<\/sup>F]SiTATE: 86.7%; [<sup>18<\/sup>F]DOPA: 73.4%;&nbsp;<em>p<\/em>\u2009=\u20090.016). Relative quantitative uptake values were not significantly different ([<sup>18<\/sup>F]SiTATE median Tumor to Background Ratio max (TBR<sub>max<\/sub>): 8.2; [<sup>18<\/sup>F]DOPA TBR<sub>max<\/sub>: 6.5;&nbsp;<em>p<\/em>\u2009=\u20090.247).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Conclusion:&nbsp;<\/strong>In this first prospective study, [<sup>18<\/sup>F]SiTATE-PET provided high tumor to background ratios in the majority of NET patients with complementary results to [<sup>18<\/sup>F]DOPA-PET.<\/p>\n","protected":false},"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"categories":[],"class_list":["post-10229","publications","type-publications","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications\/10229","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications"}],"about":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/types\/publications"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/comments?post=10229"}],"version-history":[{"count":2,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications\/10229\/revisions"}],"predecessor-version":[{"id":10231,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/publications\/10229\/revisions\/10231"}],"wp:attachment":[{"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/media?parent=10229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.m2olie.de\/en\/wp-json\/wp\/v2\/categories?post=10229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}