Quantitative Perfusionsbildgebung in der Magnetresonanztomographie


Zöllner FG, Gaa T, Zimmer F, Ong MM, Hausmann D, Schönberg SO, Weis M Der Radiologe, February 2016, Volume 56, Issue 2, pp 113-123, First online: 21 January 2016 ZusammenfassungKlinisches/methodisches Problem:Die Magnetresonanztomographie (MRT) zeichnet sich durch einen überlegenen Gewebekontrast aus, während sie nichtinvasiv und frei von ionisierender Strahlung ist. Sie bietet Zugang zu Gewebe- und

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Ultra-high pitch chest computed tomography at 70 kVp tube voltage in an anthropomorphic pediatric phantom and non-sedated pediatric patients: Initial experience with 3rd generation dual-source CT.


Hagelstein C, Henzler T, Haubenreisser H, Meyer M, Sudarski S, Schoenberg SO, Neff KW, Weis M. Zeitschrift für Medizinische Physik, Volume 26, Issue 4, December 2016, Pages 349-361, ISSN 0939-3889 AbstractPURPOSE:Minimizing radiation dose while at the same time preserving image quality is of particular importance in pediatric chest CT. Very recently, CT imaging with a

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Next Generation of SiFAlin-Based TATE Derivatives for PET Imaging of SSTR-Positive Tumors: Influence of Molecular Design on In Vitro SSTR Binding and In Vivo Pharmacokinetics.


Litau S, Niedermoser S, Vogler N, Roscher M, Schirrmacher R, Fricker G, Wängler B, Wängler C. Bioconjug Chem. 2015 Oct 14. [Epub ahead of print] The Silicon-Fluoride-Acceptor (SiFA)-18F-labeling strategy has been shown before to enable the straightforward and efficient 18F-labeling of complex biologically active substances such as proteins and peptides. Especially in the case of peptides,

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Quantitative DCE-MRI of rectal cancer: influence of multiple blood supplies and its corresponding arterial input functions on perfusion parameters


Gaa T, Sudarski S, Lietzmann F, Schad LR, Zoellner FG Magnetic Resonance Materials in Physics, Biology and Medicine, October 2015, Volume 28, Supplement 1, pp 419-519Book of Abstracts ESMRMB 2015 (e-only) p.464 (No. 597)

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Comparison of the two-compartment exchange model and the two-compartment uptake model in quantitative DCE-MRI of rectal cancer


Gaa T, Sudarski S, Lietzmann F, Schad LR, Zoellner FG Magnetic Resonance Materials in Physics, Biology and Medicine, October 2015, Volume 28, Supplement 1, pp 277-418Book of Abstracts ESMRMB 2015 (e-only) p.370 (No. 481)

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Radiation exposure of the interventional radiologist during percutaneous biopsy using a multiaxis interventional C-arm CT system with 3D laser guidance: a phantom study.


Rathmann N, Kostrzewa M, Kara K, Bartling S, Haubenreisser H, Schoenberg SO, Diehl SJ. Br J Radiol. 2015 Nov;88(1055):20150151. doi: 10.1259/bjr.20150151. Epub 2015 Sep 15. OBJECTIVE:Evaluation of absolute radiation exposure values for interventional radiologists (IRs) using a multiaxis interventional flat-panel C-arm cone beam CT (CBCT) system with three-dimensional laser guidance for biopsy in a triple-modality,

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Improving the stability of peptidic radiotracers by the introduction of artificial scaffolds: which structure element is most useful?


Bacher L, Fischer G, Litau S, Schirrmacher R, Wängler B, Baller M, Wängler C. J Labelled Comp Radiopharm. 2015 Aug;58(10):395-402. doi: 10.1002/jlcr.3315. Epub 2015 Jul 27.  Peptidic radiotracers are highly potent substances for the specific in vivo imaging of various biological targets with Single Photon Emission Computed Tomography and Positron Emission Tomography. However, some radiolabeled

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Next Step toward Optimization of GRP Receptor Avidities: Determination of the Minimal Distance between BBN(7-14) Units in Peptide Homodimers.


Fischer G, Lindner S, Litau S, Schirrmacher R, Wängler B, Wängler C. Bioconjug Chem. 2015 Aug 19;26(8):1479-83. doi: 10.1021/acs.bioconjchem.5b00362. Epub 2015 Jul 24.  As the gastrin releasing peptide receptor (GRPR) is overexpressed on several tumor types, it represents a promising target for the specific in vivo imaging of these tumors using positron emission tomography (PET).

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Accuracy of percutaneous soft-tissue interventions using a multi-axis, C-arm CT system and 3D laser guidance


Kostrzewa M, Rathmann N, Kara K, Schoenberg SO, Diehl SJ. Eur J Radiol. 2015 Jun 30. pii: S0720-048X(15)30036-X. doi: 10.1016/j.ejrad.2015.06.028. [Epub ahead of print] INTRODUCTION:Purpose of this phantom study was to compare the accuracy of needle placement using a multi-axis, C-arm-based, flat-panel, cone-beam computed tomography system (CBCT guidance) with that under multi-detector computed tomography guidance

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In Vivo Evaluation of 18F-SiFAlin–Modified TATE: A Potential Challenge for 68Ga-DOTATATE, the Clinical Gold Standard for Somatostatin Receptor Imaging with PET


Niedermoser S, Chin J, Wängler C, Kostikov A, Bernard-Gauthier V, Vogler N, Soucy JP, McEwan AJ, Schirrmacher R, and Wängler B J Nucl Med. 2015 Jul;56(7):1100-5. doi: 10.2967/jnumed.114.149583. Epub 2015 May 14. Radiolabeled peptides for tumor imaging with PET that can be produced with kits are currently in the spotlight of radiopharmacy and nuclear medicine.

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