Magnetic resonance fingerprinting for simultaneous renal T1 and T*2 mapping in a single breath‐hold


Ingo Hermann, Jorge Chacon‐Caldera, Irène Brumer, Benedikt Rieger, Sebastian Weingärtner, Lothar R. Schad, Frank G. Zöllner

First published: 03 January 2020



To evaluate the use of magnetic resonance fingerprinting (MRF) for simultaneous quantification of urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0005 and urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0006 in a single breath‐hold in the kidneys.


The proposed kidney MRF sequence was based on MRF echo‐planar imaging. Thirty‐five measurements per slice and overall 4 slices were measured in 15.4 seconds. Group matching was performed for in‐line quantification of urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0007 and urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0008. Images were acquired in a phantom and 8 healthy volunteers in coronal orientation. To evaluate our approach, region of interests were drawn in the kidneys to calculate mean values and standard deviations of the urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0009 and urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0010 times. Precision was calculated across multiple repeated MRF scans. Gaussian filtering is applied on baseline images to improve SNR and match stability.


urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0011 and urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0012 times acquired with MRF in the phantom showed good agreement with reference measurements and conventional mapping methods with deviations of less than 5% for urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0013 and less than 10% for urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0014. Baseline images in vivo were free of artifacts and relaxation times yielded good agreement with conventional methods and literature (deviation urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0015, urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0016).


In this feasibility study, the proposed renal MRF sequence resulted in accurate urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0017 and urn:x-wiley:07403194:media:mrm28160:mrm28160-math-0018 quantification in a single breath‐hold.