Cross-sectional Project 1: ProM²OLIE

Processes within the Mannheim Molecular Intervention Environment

The ProM²OLIE cross-sectional project of the M²OLIE Forschungscampus involves an organisational scientific perspective of the molecular intervention process. The overarching aim of the project is to ensure the smooth and efficient overall operation of the various sub-processes of a molecular treatment of patients both during the research phase and during the subsequent actual operation by way of a holistic process management and an integrated approach. ProM²OLIE operationalises the goal of M²OLIE to treat the patient in a so-called "one-stop shop" within a few hours. In the envisaged one-stop shop, the patient goes through the process steps of diagnosis, analysis, preparation and intervention in one day.

To achieve the M²OLIE objective, the following measures are carried out:

  • Reduction of treatment and waiting times for patients
  • Minimising operation times and amounts of capital-intensive resources (equipment and tools)
  • Consistent utilisation of available capacity
  • Minimising direct costs and maximising profit margins
  • Optimising spatial design parameters in the process

In the preliminary phase of the M²OLIE Forschungscampus the cross-sectional project has modelled the future molecular intervention process and analysed it structurally and behaviourally. In this way, initial findings on the treatment duration, costs, technologies used, intervention methods, resources and personnel were obtained.

The main phase of the ProM²OLIE cross-sectional project addresses weaknesses and the successful implementation, testing and incremental refinement of molecular intervention processes in the experimental practice operation. The molecular intervention process includes all activities patients go through, from admission to release. This process also includes logistical sub-processes for material and drug flow, based on recent modelling and simulation techniques. Preliminary cost simulations have already been conducted. The result of these simulations has implications on the administrative efficiency analysis of the molecular intervention. Further results achieved by ProM²OLIE are among others the design, development and clinical evaluation of IT solutions targeted at the removal of critical shortages in the overall process. The cross-sectional project ProM²OLIE further aims to design process definitions and control mechanisms for the planning of resources, capacity and scheduling for an IT platform. This IT platform is developed as part of Cross-Sectional Project 2 M²PROCIT.

Patient-centred, transparent, economical and time-optimised clinical treatment pathways for tumour patients.


Unsere Teammitarbeiter


Mannheim university
Prof. Dr. Armin Heinzl


Mannheim university
Dr. Kai Spohrer


Mannheim university
Okan Aydingül


Mannheim university
Ekaterina Jussupow


Fraunhofer IPA
Sebastian Schöning


Fraunhofer IPA
Dr. Ulrich Thiel


Fraunhofer IPA
Sandra Knoch


Universitätsklinikum Mannheim GmbH
Zoé I. Morgenstern

Project Head of the M²OLIE Forschungscampus:


Prof. Dr. Armin Heinzl
University of Mannheim
2. Chair of General Management and Information Systems
L 15, 1-6 - Raum 515/516
68161 Mannheim
Tel.: +49 621 181-1690
heinzl@uni-mannheim.de

Project partner:

Dipl.-Inf. Sebastian Schöning
Fraunhofer IPA
Project group for Automation in Medicine and Biotechnology PAMB
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Tel.: +49 621 1720 7123
Sebastian.Schoening@ipa.fraunhofer.de