M²oBiTE

Molecular Bioanalytics and Development of Theranostics

The aim of this lead project is the research of patient-specific diagnostic processes that should enable a rapid personalised and non-invasive endoradiotherapy as part of the closed-loop process of the research campus.

To improve the diagnosis and classification of tumour tissue by means of possible treatment targets, the molecular fingerprints of the biopsy specimens obtained in lead project 1 will be analysed by mass spectrometric and spectroscopic methods. In order to archive and analyse these molecular fingerprints, a database for systematic comparison with histopathological data will be developed and new evaluation methods will be implemented.

Using this information, research will be conducted on known and new ligands as well as antibodies and their derivatives which specifically bind to the previously identified targets. The suitability of tracers for the NIR or PET imaging and endoradiotherapy is evaluated in vitro and in vivo and then optionally optimised. Using 3D cell cultures (spheroids) obtained from the biopsy specimens, the toxicity of the radio-theranostics is analysed in vitro physiologically realistically. For this purpose, an automated tissue homogenisation with maximum cell yield is first established.

To enable a fast, highly flexible and GMP-compatible (GMP = Good Manufacturing Practice) production of the radiotracer as needed, the manual radiosyntheses for diagnostic and therapeutic nuclides are established on a synthesis module. Based on the biopsies and biodistributions a patient-specific treatment plan for endoradiotherapy based on physiologically-based pharmacokinetic models is implemented that allows the most appropriate therapeutics to be selected.

In a NIR imaging platform (NIR = Near-Infrared), various parameters are optimised in order to evaluate the 3D biodistribution of the NIR tracer preclinically under ideal conditions. In a clinical application these are intended to facilitate the (minimally) invasive removal of tumours and metastases and also to allow a multimodal imaging.

Integration into the Closed-Loop Process of M²OLIE.


Unsere Teammitarbeiter


Fraunhofer IPA
Christian Reis


Fraunhofer IPA
Stefan Scheuermann


Hochschule Mannheim
Prof. Dr. Carsten Hopf


Hochschule Mannheim
Denis Adu-Sammour


Hochschule Mannheim
Dr. Carina Ramallo Guevara


Hochschule Mannheim
Dr. Qiuqin Zhou


Hochschule Mannheim
Prof. Dr. Mathias Hafner


Hochschule Mannheim
Prof. Dr. Rüdiger Rudolf


Hochschule Mannheim
Julia Klicks


Hochschule Mannheim
Prof. Dr. Matthias Rädle


Hochschule Mannheim
Andreas Hien


Medical Faculty Mannheim, Heidelberg University
Prof. Dr. Alexander Marx


Medical Faculty Mannheim, Heidelberg University
Prof. Dr. Gerhard Glatting


Medical Faculty Mannheim, Heidelberg University
Prof. Dr. Björn Wängler


Medical Faculty Mannheim, Heidelberg University
Shanna Litau


Medical Faculty Mannheim, Heidelberg University
Maria Deligianni


Medical Faculty Mannheim, Heidelberg University
Dr. Marc Pretze


Bruker BioSpin GmbH
Dr. Jens Waldeck


Bruker BioSpin GmbH
Ali Asgar Attarwala


Leica Biosystems
Ralf Eckert


Q-bios
PD Dr. Alexander Lux


Q-bios
Dr. Heiko Flammann


Project partner

Project Head of the M²OLIE Forschungscampus:


Sub-Project-Manager of Biopsy Analytics:

Prof. Dr. Carsten Hopf
Hochschule Mannheim
Center for Applied Research
„Applied Biomedical Mass Spectrometry“ (ABIMAS)
Paul-Wittsack-Str. 10
68163 Mannheim
Tel.: +49 621 292 6802
c.hopf@hs-mannheim.de

Sub-Project-Manager of Theranostics Development:

Prof. Dr. Björn Wängler
University Medical Center Mannheim
Molecular Imaging & Radiochemistry and Biomedical Chemistry
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Tel.: +49 621 383 5594
bjoern.waengler@medma.uni-heidelberg.de

Project Head of Biopsy Analytics:
Academic partner

Prof. Dr. Alexander Marx
University Medical Center Mannheim
Institute of Pathology
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Tel.: +49 621 383 2275
alexander.marx@umm.de

Partner company

Leica Biosystems Nussloch GmbH
Im Neuenheimer Feld 519
69120 Heidelberg

Project Head of Theranostics Development:
Academic partner

Christian Reis
Fraunhofer IPA
Project group for Automation in Medicine and Biotechnology PAMB
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Tel.: +49 621 1720 7154
Christian.Reis@ipa.fraunhofer.de

Prof. Dr. Mathias Hafner
Hochschule Mannheim
Institute of Molecular- and Cell Biology
Paul-Wittsack-Str. 10
68163 Mannheim
Tel.: +49 621 292 6538
m.hafner@hs-mannheim.de

Prof. Dr. Rüdiger Rudolf
Hochschule Mannheim
Institute of Molecular- and Cell Biology
Paul-Wittsack-Str. 10
68163 Mannheim
Tel.: +49 621 292 6804
r.rudolf@hs-mannheim.de

Prof. Dr. Matthias Rädle
Hochschule Mannheim
Institute of Metrology and Innovative Energy Systems
Paul-Wittsack-Str. 10
68163 Mannheim
Tel.: +49 621 76150821
m.raedle@hs-mannheim.de

Prof. Dr. Gerhard Glatting
University Medical Center Mannheim
radiophysics/radioprotection
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
gerhard.glatting@medma.uni-heidelberg.de

Partner company

Bruker BioSpin MRI GmbH
Rudolf-Plank-Str. 23
76275 Ettlingen

Q-bios GmbH
Paul-Wittsack-Str. 10
68163 Mannheim