Lead Project 1

Development of a system platform for M²INT minimally invasive molecular assisted intervention

M²INT Lead Project 1 deals with the development of a semi-automated intervention system for the efficient implementation of minimally invasive individualised treatment using radiology and radiotherapy on oligometastatic patients.

The focus in the first phase is the integration of clinical procedures of interventional radiology, e.g. biopsy and radiotherapy, e.g. brachytherapy, into the intervention system. In a second step, procedures for minimally invasive surgery and scarless surgery (NOTES) will be integrated.

The aim is to shorten the time taken to perform the procedure while increasing precision so as to ensure that the treatment (biopsy, diagnosis, treatment) of oligometastatic patients can be performed in a continuous procedure lasting a maximum of one day (one-stop shop) and so that the increased technical effort is economically justified. This goal will be achieved through the use of assistance systems and by increasing the level of automation.

Work and Research Areas of M²INT:
  • Development of an intervention assistant and integration of the Artis ZEEGO® system for automatic instrument positioning using the instrument change system
  • Development of a "smart" biopsy needle for tissue classification and differentiation of tumourous and normal tissue
  • Development of a navigation system that can detect all persons and objects in the intervention area
  • Examination of an automatic registration procedure
  • Development of an app concept for interventions using the Artis ZEEGO® System

The long-term goal of medical treatment in a closed circuit (closed-loop process) requires the development of interfaces for the integration of diagnostics and bioanalytics as well as for the production of diagnostics or therapeutics (M²oBiTE) directly on or in the intervention area. These Interfaces are created in the first phase, and in the second phase of the process will be evaluated experimentally in the intervention area.

Currently participating as industrial partners in the M²INT lead project are the companies Siemens Healthcare GmbH, KUKA Laboratories GmbH, Carl Zeiss Meditec AG and MAQUET GmbH.

Partners from the academic/scientific field include: the Institute for Clinical Radiology and Nuclear Medicine at the university hospital of Mannheim, the Department of Radiation Oncology at the university hospital of Mannheim, the Institute for Scientific Computing (Heidelberg), the Institute of Embedded Systems and Medical Technology (EMB-Lab) of the university of Mannheim, the Fraunhofer project group for Automation in Medicine and Biotechnology of Fraunhofer IPA (Mannheim).

Shortening the intervention processes, precise navigation through optimized imaging (M²IBID), immediate delivery of tissue samples for analysis and application of diagnostics and therapeutics (M²oBiTE).


Unsere Teammitarbeiter


Fraunhofer IPA
Prof. Dr. Jan Stallkamp


Fraunhofer IPA
Andreas Rothfuss


Fraunhofer IPA
Armin Schäfer


Fraunhofer IPA
Marius Siegfarth


Hochschule Mannheim
Prof. Dr. Marcus Vetter


Hochschule Mannheim
Alina Keller


University Medical Center Mannheim
Prof. Dr. Steffen Diehl


Medical Faculty Mannheim, Heidelberg University
Arman Smakic


Heidelberg University
Dr. Sven Clausen


Heidelberg University
Dr. Daniel Bürgy


Project partner

Project Head of the M²OLIE Forschungscampus:


Prof. Dr. Jan Stallkamp
Fraunhofer IPA
Project group for Automation in Medicine and Biotechnology PAMB
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Tel.: +49 172 07101
jan.stallkamp@ipa.fraunhofer.de

Project partner:
Academic partner

Prof. Dr. Marcus Vetter
Hochschule Mannheim
Institute of Embedded Systems and Medical Engineering (EMB-Lab)
Faculty of Information Technology
Paul-Wittsack-Str. 10
68163 Mannheim
Tel.: +49 621 292 6347
m.vetter@hs-mannheim.de

Prof. Dr. Steffen Diehl
University Medical Center Mannheim
Institute of Clinical Radiology and Nuclear Medicine
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Tel.: +49 621 383 5097
steffen.diehl@umm.de

Prof. Dr. Frederik Wenz
University Medical Center Mannheim
Institute of Clinical Radiology and Radiation Oncology
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Tel.: +49 621 383 4960
frederik.wenz@medma.uni-heidelberg.de

Partner company

Carl Zeiss Meditec AG
Rudolf-Eber-Str. 11
73447 Oberkochern

KUKA Laboratories GmbH
Zugspitzstr. 140
86165 Augsburg

MAQUET GmbH
Kehler Straße 31
76437 Rastatt

Siemens Healthcare GmbH
Siemensstr. 1
91301 Forchheim